Despoina (Δέσποινα) is the Greek word for "lady" or "mistress of the house" — an ancient epithet of Persephone and an Eleusinian goddess in her own right. In modern Greek, despoina is still the word for "Mrs." or "lady."
Despoina is widely used in Greece.
Despoina does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
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In Pythagorean numerology the letters of Despoina reduce to 2, The Peacemaker. This is a traditional interpretive system, not a factual claim about the name.