Guadalupe is from the Spanish Guadalupe — from Arabic wadi (river) + Latin lupus (wolf) — river of the wolf also possible from Arabic al-Lupp. Guadalupe is one of the Spanish + Latin American feminine names — central to traditional Mexican Catholic heritage.
Guadalupe does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
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In Pythagorean numerology the letters of Guadalupe reduce to 7, The Seeker. This is a traditional interpretive system, not a factual claim about the name.