Karen is the Danish form of Katherine — from the Greek katharos (pure).
Karen does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Karen reduce to 4, The Builder. This is a traditional interpretive system, not a factual claim about the name.