Lois (Λωΐς) is a Greek name of uncertain meaning — possibly "most desired" or "agreeable." In the New Testament, Lois is the grandmother of Timothy (2 Timothy 1:5).
Lois peaked at #15 in the U.S. in 1934.
Lois does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Lois reduce to 1, The Leader. This is a traditional interpretive system, not a factual claim about the name.